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Different species of atomic nuclei which contain the same number of protons (and thus represent the same chemical element), but different numbers of neutrons, are called isotopes.

Thus, helium-4 (two protons, two neutrons) and helium-3 (two protons, one neutron) are isotopes, but helium-3 and tritium (one proton, two neutrons) are not. The word can also be used of a specific species of nucleus and a generic chemical element, as in "helium-3 is an isotope of helium".